P1.04: Defining the Genetic Architecture of Lung Cancer Etiology

Molecular Genetic Etiology of Prostate Cancer

Prostate Cancer (PCa) is the most frequently diagnosed non-skin cancer and second leading cause of cancer deaths after lung cancer in the western industrialized countries. It varies widely by geographic location and ethnicity. It is clinically heterogeneous, complex and indeed a multi-factorial disease. While the majority of PCa is sporadic, as much as up to 40% of the cases are associated with...

Genetic etiology of Asthenozoospermia: A review

Background: Asthenozoospermia, as the most prevalent cause of male infertility, is defined as low percentage of progressively motile spermatozoa per ejaculate. It occurs in both non-syndromic and syndromic forms and later it manifests as a part of primary ciliary dyskinesia. In the last decade, with the advent of Next-generation sequencing technologies numerous genes have been introduced in the...

GENETIC AND NON-GENETIC THEORIES ON THE ETIOLOGY OF POLYCYSTIC OVARY SYNDROME: A REVIEW

Evidence for the Genetic Etiology of Prostate Cancer

cancer diagnosed in North American men, excluding skin cancers. It is estimated that, in 2004, approximately 230,110 new cases and 29,900 prostate cancer-related deaths will occur in the United States [1]. In Australia, one in 11 men will develop the disease during their lifetime [2]. The annual number of new cases registered in England and Wales increased by over threefold between 1971 and 200...

Defining the biological basis of radiomic phenotypes in lung cancer

Medical imaging can visualize characteristics of human cancer noninvasively. Radiomics is an emerging field that translates these medical images into quantitative data to enable phenotypic profiling of tumors. While radiomics has been associated with several clinical endpoints, the complex relationships of radiomics, clinical factors, and tumor biology are largely unknown. To this end, we analy...